Retinitis pigmentosa is a highly heterogenous disease with now over 200 known driver genes. With such high hetergeneity, RPGeNet, a web application tool, was created to help users find new potential driver genes of retinitis pigmentosa and help better visualize the complex interaction network of the retina. The interaction database is formed by the merger of self-curated BioGRID, STRING and text-mining (PPaxe) interaction data. The database is managed by neo4j and the graph's visual display is created by Cytoscape.js.
Distilling a Visual Network of Retinitis Pigmentosa Gene-Protein Interactions to Uncover New Disease Candidates.
Daniel Boloc, Sergio Castillo-Lara, Gemma Marfany, Roser Gonzàlez-Duarte and Josep F. Abril.
PLoS ONE, 2015, 10(8): e0135307